Katie Reding and Leslie Pick’s paper, High Efficiency CRISPR/Cas9 Mutagenesis of the white Gene in the Milkweed Bug Oncopeltus fasciatus has been chosen for GSA journals’ 2020 Spotlight Collection of research and scholarship. The collection curated by the editors showcases noteworthy examples of genetics and genomics investigations. Congratulations to the Pick Lab for this exciting recognition!
Visit the collection here: https://academic.oup.com/genetics/pages/spotlight
More on the article: Entomology graduate student Katie Reding (Pick lab) used CRISPR/Cas9 to make a genomic deletion of the white gene in the milkweed bug Oncopeltus fasciatus. The white gene was one of the first genes identified in Drosophila, over 100 years ago, where it is necessary for the red eye color of flies. Interesting, in Oncopeltus, white is necessary for pigmentation throughout the body but it is also necessary for organismal survival, as animals homozygous for the white mutations do not survive to adulthood. This is the first demonstration that CRISPR is effective in Oncopeltus. Methods Katie developed will be useful for researchers to test the function of other genes in this and related species.